Literature summary extracted from

Alborn, W.E.; Cao, G.; Careskey, H.E.; Qian, Y.W.; Subramaniam, D.R.; Davies, J.; Conner, E.M.; Konrad, R.J.
Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol (2007), Clin. Chem., 53, 1814-1819.

Application

EC Number	Application	Comment	Organism
3.4.21.61	medicine	circulating concentrations of human PCSK9 are directly correlated with LDL and total cholesterol concentrations. PCSK9 is likely not associated with specific lipoprotein particles. Assay providing a means to tailor PCSK9-inhibitor therapy to patients most likely to respond to and benefit from pharmacologic inhibition of PCSK9	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.61	overexpressed in HEK-293 cells	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.61	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.4.21.61	by Ni-nitriloacetic acid and size-exclusion chromatography, more than 95% pure	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.61	serum	concentrations of PCSK9 in serum vary considerably from person to person	Homo sapiens	-

Storage Stability

EC Number	Storage Stability	Organism
3.4.21.61	-70°C	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.61	PCSK9	-	Homo sapiens
3.4.21.61	proprotein convertase subtilisin kexin type 9	-	Homo sapiens

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Release 2023.1 (January 2023)